TISSUE RESPONSE TO WHITE AND GRAY MINERAL TRIOXIDE AGGREGATE (MTA) IMPLANTED IN TIBIAL BONE DEFECTS OF RATS.
Revista de Ciências Médicas - Jan 2008 v. 17 n.1
Background: MTA is biocompatible and presents adequate mechanical properties to be implanted in bone fractures. Bone tissue response to gray and white MTA was evaluated according to the period after implantation.
Methods: MTA was implanted in tibia bone defects of sixteen Wistar, adult, male, rats. Gray MTA was implanted in the left hind leg, while white MTA was implanted in the right hind leg of the rats. Control group comprised 16 animals. Tissue samples for morphological and morphometric evaluations were removed two, four, eight and 16 weeks after implantation. TPS Dig 1.38 software was used for histological analysis. Statistical analysis used ANOVA followed by Tukey Test (p<0.05).
Results: MTA was identified in the periosteum region and adjacent connective tissues, but not within bone matrix. Osteoblastic proliferation and primary bone formation, such as that found in control group, were observed in fracture areas. Cellular infiltrate, which could indicate an inflammatory process, was not observed in the periosteum region. Abnormal collagen fibers deposition or neoformed blood vessels were not significantly detected. Significant morphometric differences were not established between both MTA materials.
Conclusions: Both types of MTA, in the experimental conditions, did not significantly interfere in the healing process of the bone defect.
Autores:
Pedro Paulo Barros, Rodrigo Sanches Cunha, Gustavo Henrique Silva e Carlos Eduardo da S Bueno
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